On the path to [Fe-S] protein maturation: A personal perspective.
Biochim Biophys Acta Mol Cell Res
; 1871(6): 119750, 2024 Aug.
Article
de En
| MEDLINE
| ID: mdl-38762171
ABSTRACT
Azotobacter vinelandii is a genetically tractable Gram-negative proteobacterium able to fix nitrogen (N2) under aerobic growth conditions. This narrative describes how biochemical-genetic approaches using A. vinelandii to study nitrogen fixation led to the formulation of the "scaffold hypothesis" for the assembly of both simple and complex [Fe-S] clusters associated with biological nitrogen fixation. These studies also led to the discovery of a parallel, but genetically distinct, pathway for maturation of [Fe-S] proteins that support central metabolic processes.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines bactériennes
/
Azotobacter vinelandii
/
Ferrosulfoprotéines
/
Fixation de l'azote
Langue:
En
Journal:
Biochim Biophys Acta Mol Cell Res
/
Biochim. biophys. acta, Mol. cell res
/
Biochimica et biophysica acta
Année:
2024
Type de document:
Article
Pays de publication:
Pays-Bas