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Cervical percutaneous interferential current stimulation improves citric acid cough tests in patients with Parkinson's disease on medication.
Nakamori, Masahiro; Toko, Megumi; Yamada, Hidetada; Hayashi, Yuki; Ushio, Kai; Yoshikawa, Kohei; Hiraoka, Aya; Yoshikawa, Mineka; Nagasaki, Toshikazu; Shimizu, Yoshitaka; Mikami, Yukio; Maruyama, Hirofumi.
Affiliation
  • Nakamori M; Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan. mnakamori1@gmail.com.
  • Toko M; Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Yamada H; Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Hayashi Y; Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Ushio K; Department of Rehabilitation Medicine, Hiroshima University Hospital, Hiroshima, Japan.
  • Yoshikawa K; Department of Rehabilitation Medicine, Hiroshima University Hospital, Hiroshima, Japan.
  • Hiraoka A; Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Yoshikawa M; Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Nagasaki T; Department of Oral and Maxillofacial Radiology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Shimizu Y; Department of Dental Anesthesiology, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
  • Mikami Y; Department of Rehabilitation Medicine, Hiroshima University Hospital, Hiroshima, Japan.
  • Maruyama H; Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Sci Rep ; 14(1): 11386, 2024 05 18.
Article de En | MEDLINE | ID: mdl-38762573
ABSTRACT
Aspiration pneumonia is the leading cause of death in patients with Parkinson's disease. The incidence of silent aspiration is high in such patients owing to decreased pharyngeal and laryngeal sensation; thus, interventions for this condition may help prevent pneumonia. In this single-arm, open-label study, we used a cervical percutaneous interferential current stimulation device to activate pharyngeal and laryngeal sensory nerves. We evaluated its effectiveness in patients with Hoehn-Yahr stages 2-4 Parkinson's disease. The primary endpoint was the proportion of patients with a normal cough reflex after consuming 1% citric acid at the end of the intervention compared with baseline measurements. In total, 25 patients received neck percutaneous interferential current stimulation for 20 min twice weekly for 8 weeks. Afterward, the proportion of patients with a normal cough reflex after 1% citric acid consumption increased significantly (p = 0.001), whereas other indicators, such as tongue pressure, peak expiratory flow, and penetration or aspiration during videofluoroscopic examination, remained unchanged. A longer duration of illness, higher Unified Parkinson's Disease Rating Scale total scores, and higher levodopa equivalent daily doses were significantly associated with improved cough test outcomes. Hence, cervical percutaneous interferential current stimulation significantly improved cough reflexes and may improve silent aspiration. Trial Registration Japan Registry of Clinical Trials, jRCTs062220013, first registered 09/05/2022.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie de Parkinson / Acide citrique / Toux Limites: Aged / Female / Humans / Male / Middle aged Langue: En Journal: Sci Rep Année: 2024 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie de Parkinson / Acide citrique / Toux Limites: Aged / Female / Humans / Male / Middle aged Langue: En Journal: Sci Rep Année: 2024 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni