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NRF2-mediated regulation of lipid pathways in viral infection.
Muzammil, Khursheed; Sabah Ghnim, Zahraa; Saeed Gataa, Ibrahim; Fawzi Al-Hussainy, Ali; Ali Soud, Nashat; Adil, Mohaned; Ali Shallan, Mohammed; Yasamineh, Saman.
Affiliation
  • Muzammil K; Department of Public Health, College of Applied Medical Sciences, Khamis Mushait Campus, King Khalid University, Abha, 62561, Saudi Arabia.
  • Sabah Ghnim Z; Department of Pharmacy, Al-Noor University, Nineveh, Mosul, Iraq.
  • Saeed Gataa I; Warith Al-Anbiyaa University, Karbala, 56001, Iraq.
  • Fawzi Al-Hussainy A; College of Pharmacy, Ahl Al Bayt University, Kerbala, Iraq.
  • Ali Soud N; Collage of Dentist, National University of Science and Technology, Dhi Qar, 64001, Iraq.
  • Adil M; Pharmacy college, Al-Farahidi University, Iraq.
  • Ali Shallan M; College of Dentistry, Al-Mustaqbal University, 51001, Babylon, Iraq.
  • Yasamineh S; Young Researchers and Elite Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran. Electronic address: yassaman124@gmail.com.
Mol Aspects Med ; 97: 101279, 2024 06.
Article de En | MEDLINE | ID: mdl-38772081
ABSTRACT
The first line of defense against viral infection of the host cell is the cellular lipid membrane, which is also a crucial first site of contact for viruses. Lipids may sometimes be used as viral receptors by viruses. For effective infection, viruses significantly depend on lipid rafts during the majority of the viral life cycle. It has been discovered that different viruses employ different lipid raft modification methods for attachment, internalization, membrane fusion, genome replication, assembly, and release. To preserve cellular homeostasis, cells have potent antioxidant, detoxifying, and cytoprotective capabilities. Nuclear factor erythroid 2-related factor 2 (NRF2), widely expressed in many tissues and cell types, is one crucial component controlling electrophilic and oxidative stress (OS). NRF2 has recently been given novel tasks, including controlling inflammation and antiviral interferon (IFN) responses. The activation of NRF2 has two effects it may both promote and prevent the development of viral diseases. NRF2 may also alter the host's metabolism and innate immunity during viral infection. However, its primary function in viral infections is to regulate reactive oxygen species (ROS). In several research, the impact of NRF2 on lipid metabolism has been examined. NRF2 is also involved in the control of lipids during viral infection. We evaluated NRF2's function in controlling viral and lipid infections in this research. We also looked at how lipids function in viral infections. Finally, we investigated the role of NRF2 in lipid modulation during viral infections.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladies virales / Stress oxydatif / Facteur-2 apparenté à NF-E2 / Métabolisme lipidique Limites: Animals / Humans Langue: En Journal: Mol Aspects Med / Mol. aspects med / Molecular aspects of medicine Année: 2024 Type de document: Article Pays d'affiliation: Arabie saoudite Pays de publication: Royaume-Uni

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladies virales / Stress oxydatif / Facteur-2 apparenté à NF-E2 / Métabolisme lipidique Limites: Animals / Humans Langue: En Journal: Mol Aspects Med / Mol. aspects med / Molecular aspects of medicine Année: 2024 Type de document: Article Pays d'affiliation: Arabie saoudite Pays de publication: Royaume-Uni