Cannflavin A inhibits TLR4-induced chemokine and cytokine expression in human macrophages.
Nat Prod Res
; : 1-7, 2024 May 23.
Article
de En
| MEDLINE
| ID: mdl-38780010
ABSTRACT
Cannflavin A (CFL-A), a flavonoid present in the hemp plant Cannabis sativa L. (C. sativa), has anti-inflammatory and neuroprotective capacity. Research continues to elucidate the anti-inflammatory effects of components of C. sativa, with evidence that plant-derived cannabinoids and terpenes can mediate anti-inflammatory activity by targeting toll-like receptor (TLR) signalling, the sensors of pathogen-associated molecules. This study set out to determine if TLR-mediated inflammatory signalling is a CFL-A target using the endotoxin lipopolysaccharide (LPS) to induce TLR4 signalling in human THP-1-derived macrophages. TLR4 activation promoted the production of the chemokine CXCL10 and cytokines IL-1ß and TNFα. Treatment with CFL-A dose-dependently attenuated TLR4-induced CXCL10 and IL-1ß secretion, with our findings also indicating that the inhibitory effects of CFL-A on chemokine/cytokine secretion are in line with an NF-κB inhibitor. This study highlights TLR4 signalling as a cannflavin target in macrophages.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
Nat Prod Res
/
Nat. prod. res. (Online)
/
Natural product research (Online)
Année:
2024
Type de document:
Article
Pays d'affiliation:
Irlande
Pays de publication:
Royaume-Uni