Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung.
Front Immunol
; 15: 1382655, 2024.
Article
de En
| MEDLINE
| ID: mdl-38803494
ABSTRACT
Introduction:
Global microplastic (MP) pollution is now well recognized, with humans and animals consuming and inhaling MPs on a daily basis, with a growing body of concern surrounding the potential impacts on human health.Methods:
Using a mouse model of mild COVID-19, we describe herein the effects of azide-free 1 µm polystyrene MP beads, co-delivered into lungs with a SARS-CoV-2 omicron BA.5 inoculum. The effect of MPs on the host response to SARS-CoV-2 infection was analysed using histopathology and RNA-Seq at 2 and 6 days post-infection (dpi).Results:
Although infection reduced clearance of MPs from the lung, virus titres and viral RNA levels were not significantly affected by MPs, and overt MP-associated clinical or histopathological changes were not observed. However, RNA-Seq of infected lungs revealed that MP exposure suppressed innate immune responses at 2 dpi and increased pro-inflammatory signatures at 6 dpi. The cytokine profile at 6 dpi showed a significant correlation with the 'cytokine release syndrome' signature observed in some COVID-19 patients.Discussion:
The findings are consistent with the recent finding that MPs can inhibit phagocytosis of apoptotic cells via binding of Tim4. They also add to a growing body of literature suggesting that MPs can dysregulate inflammatory processes in specific disease settings.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Modèles animaux de maladie humaine
/
Microplastiques
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SARS-CoV-2
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COVID-19
/
Immunité innée
/
Poumon
Limites:
Animals
/
Female
/
Humans
Langue:
En
Journal:
Front Immunol
/
Front. immunol
/
Frontiers in immunology
Année:
2024
Type de document:
Article
Pays d'affiliation:
Australie
Pays de publication:
Suisse