Dose-response and efficacy of 904 nm photobiomodulation on diabetic foot ulcers healing: a randomized controlled trial.
Lasers Med Sci
; 39(1): 142, 2024 May 28.
Article
de En
| MEDLINE
| ID: mdl-38805069
ABSTRACT
PURPOSE:
This study aimed to examine the impact of a 904 nm photobiomodulation (PBM) on diabetic ulcers using varying dosages.METHODS:
The study was a randomized, double-blind, placebo-controlled clinical trial that compared treatments using PBM (GaAs 904 nm 30w) with three different energy densities (4 J/cm2; 8 J/cm2; 10 J/cm2) in the healing process of non-infected diabetic foot ulcers. Eighty volunteers (48.75% female; 58.5 ± 11.1 years) were randomized into three intervention groups treated with PBM and one control group (PBM placebo). Volunteers performed up 20 interventions with PBM, either placebo or actual, in conjunction with conventional therapy, which involved dressing the wound with Helianthus annuus vegetable oil. The primary variable was the ulcer size reduction rate.RESULTS:
GaAs 904 nm PBM yielded a clinically and significant ulcer size rate reduction of diabetic foot ulcers, independently of energy density range (p < 0.05). However, 10 J/cm² had 60% of completely healed ulcers and the highest proportion of patients reaching 50% of ulcer reduction rate after 5 weeks of treatment. In addition, only 10 J/cm² showed a significant difference between control group after a 10-week follow-up (p < 0.05).CONCLUSION:
GaAs 904 nm PBM was effective in treating diabetic foot ulcers in this study and a dosage of 10 J/cm², after a 10-week follow-up, proved to be the most effective compared to the other groups. CLINICAL TRIAL REGISTRATION NUMBER NCT04246814.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cicatrisation de plaie
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Pied diabétique
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Photothérapie de faible intensité
Limites:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
Langue:
En
Journal:
Laser in medical science
/
Lasers Med Sci
/
Lasers med. sci
Sujet du journal:
BIOTECNOLOGIA
/
RADIOLOGIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Brésil
Pays de publication:
Royaume-Uni