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Erythrocyte membrane fatty acid concentrations and myelin integrity in young people at ultra-high risk of psychosis.
Collins, Melissa; Bartholomeusz, Cali; Mei, Cristina; Kerr, Melissa; Spark, Jessica; Wallis, Nicky; Polari, Andrea; Baird, Shelley; Buccilli, Kate; Dempsey, Sarah-Jane A; Ferguson, Natalie; Formica, Melanie; Krcmar, Marija; Quinn, Amelia L; Wannan, Cassandra; Oldham, Stuart; Fornito, Alex; Mebrahtu, Yohannes; Ruslins, Arlan; Street, Rebekah; Loschiavo, Keana; McGorry, Patrick D; Nelson, Barnaby; Amminger, G Paul.
Affiliation
  • Collins M; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia. Electronic address: m-sellies@outlook.com.
  • Bartholomeusz C; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Mei C; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Kerr M; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Spark J; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Wallis N; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Polari A; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Baird S; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Buccilli K; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Dempsey SA; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Ferguson N; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Formica M; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Krcmar M; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Quinn AL; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Wannan C; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Oldham S; Monash Data Futures Institute, Monash University, Clayton, Australia.
  • Fornito A; Monash Data Futures Institute, Monash University, Clayton, Australia.
  • Mebrahtu Y; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Ruslins A; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Street R; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Loschiavo K; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia.
  • McGorry PD; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Nelson B; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
  • Amminger GP; Orygen, 35 Poplar Road, Melbourne, VIC 3052, Australia; Centre for Youth Mental Health, University of Melbourne, Melbourne, Australia.
Psychiatry Res ; 337: 115966, 2024 Jul.
Article de En | MEDLINE | ID: mdl-38810536
ABSTRACT
Decreased white matter (WM) integrity and disturbance in fatty acid composition have been reported in individuals at ultra-high risk of psychosis (UHR). The current study is the first to investigate both WM integrity and erythrocyte membrane polyunsaturated fatty acid (PUFA) levels as potential risk biomarkers for persistent UHR status, and global functioning in UHR individuals. Forty UHR individuals were analysed at baseline for erythrocyte membrane PUFA concentrates. Tract-based spatial statistics (TBSS) was used to analyse fractional anisotropy (FA) and diffusivity measures. Measures of global functioning and psychiatric symptoms were evaluated at baseline and at 12-months. Fatty acids and WM indices did not predict functional outcomes at baseline or 12-months. Significant differences were found in FA between UHR remitters and non-remitters (individuals who no longer met UHR criteria versus those who continued to meet criteria at 12-months). Docosahexaenoic acid (DHA) was found to be a significant predictor of UHR status at 12-months, as was the interaction between the sum of ώ-3 and whole brain FA, and the interaction between the right anterior limb of the internal capsule and the sum of ώ-3. The results confirm that certain fatty acids have a unique relationship with WM integrity in UHR individuals.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Troubles psychotiques / Membrane érythrocytaire / Gaine de myéline Limites: Adolescent / Adult / Female / Humans / Male Langue: En Journal: Psychiatry Res Année: 2024 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Troubles psychotiques / Membrane érythrocytaire / Gaine de myéline Limites: Adolescent / Adult / Female / Humans / Male Langue: En Journal: Psychiatry Res Année: 2024 Type de document: Article