Alternative platelet differentiation pathways initiated by nonhierarchically related hematopoietic stem cells.
Nat Immunol
; 25(6): 1007-1019, 2024 Jun.
Article
de En
| MEDLINE
| ID: mdl-38816617
ABSTRACT
Rare multipotent stem cells replenish millions of blood cells per second through a time-consuming process, passing through multiple stages of increasingly lineage-restricted progenitors. Although insults to the blood-forming system highlight the need for more rapid blood replenishment from stem cells, established models of hematopoiesis implicate only one mandatory differentiation pathway for each blood cell lineage. Here, we establish a nonhierarchical relationship between distinct stem cells that replenish all blood cell lineages and stem cells that replenish almost exclusively platelets, a lineage essential for hemostasis and with important roles in both the innate and adaptive immune systems. These distinct stem cells use cellularly, molecularly and functionally separate pathways for the replenishment of molecularly distinct megakaryocyte-restricted progenitors a slower steady-state multipotent pathway and a fast-track emergency-activated platelet-restricted pathway. These findings provide a framework for enhancing platelet replenishment in settings in which slow recovery of platelets remains a major clinical challenge.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plaquettes
/
Cellules souches hématopoïétiques
/
Mégacaryocytes
/
Différenciation cellulaire
Limites:
Animals
/
Humans
Langue:
En
Journal:
Nat Immunol
/
Nat. immunol
/
Nature immunology
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2024
Type de document:
Article
Pays de publication:
États-Unis d'Amérique