On the participation of glycine receptors in the reconsolidation of spatial long-term memory in male rats.
Behav Brain Res
; 471: 115086, 2024 08 05.
Article
de En
| MEDLINE
| ID: mdl-38825024
ABSTRACT
The effects of intra-hippocampal manipulation of glycine receptors on the reconsolidation of recent and late long-term spatial memory were evaluated and assessed in the Morris water maze. The results obtained from the intra-hippocampal infusion of glycine and taurine demonstrated that taurine at a 100 nmol/side dose impaired the reconsolidation of recent and late long-term spatial memory. In comparison, at a dose of 10 nmol/side, it only affected the reconsolidation of late long-term spatial memory, reinforcing that there are differences between molecular mechanisms underlying recent and late long-term memory reconsolidation. On the other hand, glycine impaired the reconsolidation of early and late spatial memory when infused at a dose of 10 nmol/side, but not at a dose of 100 nmol/side, unless it is co-infused with an allosteric site antagonist of the NMDA receptor. Altogether these results show that glycine acting in situ in the hippocampal CA1 region exerts a pharmacological effect on U-curve, which can be explained by its concomitant action on its ionotropic receptor GlyR and on its NMDA receptor co-agonist site.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Taurine
/
Rat Wistar
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Récepteur de la glycine
/
Mémoire à long terme
/
Mémoire spatiale
/
Glycine
Limites:
Animals
Langue:
En
Journal:
Behav Brain Res
/
Behav. brain res
/
Behavioural brain research
Année:
2024
Type de document:
Article
Pays de publication:
Pays-Bas