Enantioselective formal total synthesis of dihydrospirotryprostatin B.
J Asian Nat Prod Res
; : 1-17, 2024 Jun 03.
Article
de En
| MEDLINE
| ID: mdl-38829012
ABSTRACT
Spirotryprostatins are representative members of medicinally interesting bioactive molecules of the spirooxindole natural products. In this communication, we present a novel enantioselective total synthesis of the spirooxindole alkaloid dihydrospirotryprostatin B. The synthesis takes advantage of copper-catalyzed tandem reaction of o-iodoanilide chiral sulfinamide derivatives with alkynone to rapidly construct the key quaternary carbon stereocenter of the natural product dihydrospirotryprostatin B.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
J Asian Nat Prod Res
Sujet du journal:
BOTANICA
/
QUIMICA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine