Low-calorie diet-induced weight loss is associated with altered brain connectivity and food desire in obesity.
Obesity (Silver Spring)
; 32(7): 1362-1372, 2024 07.
Article
de En
| MEDLINE
| ID: mdl-38831482
ABSTRACT
OBJECTIVE:
The main objective of this study is to better understand the effects of diet-induced weight loss on brain connectivity in response to changes in glucose levels in individuals with obesity.METHODS:
A total of 25 individuals with obesity, among whom 9 had a diagnosis of type 2 diabetes, underwent functional magnetic resonance imaging (fMRI) scans before and after an 8-week low-calorie diet. We used a two-step hypereuglycemia clamp approach to mimic the changes in glucose levels observed in the postprandial period in combination with task-mediated fMRI intrinsic connectivity distribution (ICD) analysis.RESULTS:
After the diet, participants lost an average of 3.3% body weight. Diet-induced weight loss led to a decrease in leptin levels, an increase in hunger and food intake, and greater brain connectivity in the parahippocampus, right hippocampus, and temporal cortex (limbic-temporal network). Group differences (with vs. without type 2 diabetes) were noted in several brain networks. Connectivity in the limbic-temporal and frontal-parietal brain clusters inversely correlated with hunger.CONCLUSIONS:
A short-term low-calorie diet led to a multifaceted body response in patients with obesity, with an increase in connectivity in the limbic-temporal network (emotion and memory) and hormone and eating behavior changes that may be important for recovering the weight lost.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Encéphale
/
Imagerie par résonance magnétique
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Perte de poids
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Faim
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Restriction calorique
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Diabète de type 2
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Obésité
Limites:
Adult
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Female
/
Humans
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Male
/
Middle aged
Langue:
En
Journal:
Obesity (Silver Spring)
Sujet du journal:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
METABOLISMO
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique