Comparison of Various Therapeutic Approaches to Manage Infertility in Polycystic Ovarian Syndrome.
J Coll Physicians Surg Pak
; 34(6): 654-658, 2024 Jun.
Article
de En
| MEDLINE
| ID: mdl-38840346
ABSTRACT
OBJECTIVE:
To compare the efficacies of common therapeutic regimens and their combinations, used in polycystic ovarian syndrome (PCOS) to improve fertility in reproductive-age women. STUDYDESIGN:
A descriptive study. Place and Duration of the Study Department of Obstetric Gynaecologist, Medicare Cardiac and General Hospital, Karachi, Pakistan, from November 2022 to July 2023.METHODOLOGY:
Out of 300 patients with the symptoms of menstrual irregularities and infertility, 152 were diagnosed as PCOS patients based on the ultrasound and hormonal assays and selected for study purpose. They were divided according to their therapeutic regimen into four treatment groups, treated by different therapeutic agents. Group A received metformin 500 mg/day (n = 38); Group B received metformin + myo-inositol 1g (n = 49); Group C received metformin + letrozole 2.5 mg (n = 36), and Group D received metformin + letrozole + myo-inositol (n = 29), orally for three months. All continuous variables, such as body mass index (BMI), FSH, LH, FT4, and FSI were analysed by applying t-test to all therapeutic groups, keeping p ≤0.05 as the level of significance.RESULTS:
HCG-positive was found as 86% (n = 33) in Group A, 63% (n = 31) in Group B, 52% (n = 19) in Group C, and 27% (n = 08) in Group D. There were statistically significant (p <0.001) changes in BMI, FSH, LH, FT4, and FSI as well. Metformin alone and metformin plus myo-inositol came out to be more effective than other regimens.CONCLUSION:
Metformin alone and myo-inositol plus metformin are effective therapeutic options in PCOS-induced infertility problems. KEY WORDS Polycystic ovarian syndrome, Infertility, Metformin, Myo-inositol, Letrozole, Menstrual irregularities.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Syndrome des ovaires polykystiques
/
Association de médicaments
/
Létrozole
/
Infertilité féminine
/
Inositol
/
Metformine
Limites:
Adult
/
Female
/
Humans
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
J Coll Physicians Surg Pak
Sujet du journal:
MEDICINA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Pakistan