IgA multiple myeloma-associated mediastinal spinal plasmacytoma presenting as spinal cord compression.
BMJ Case Rep
; 17(6)2024 Jun 06.
Article
de En
| MEDLINE
| ID: mdl-38844357
ABSTRACT
Multiple myeloma associated with extramedullary plasmacytoma at initial presentation is rare. We describe a case of a man in his 30s who initially presented with symptoms of spinal cord compression. Further imaging revealed a mediastinal tumour, with a biopsy confirming plasmacytoma. Immunofixation revealed IgA lambda paraprotein. Bone marrow biopsy demonstrated atypical T-cell cytotoxic proliferation and trilineage hypoplasia. The patient was diagnosed with extramedullary plasmacytoma with active IgA multiple myeloma. The patient received mediastinal radiation to the tumour, followed by anti-myeloma therapy. This diagnosis is critical as managing a solitary plasmacytoma drastically differs from an extramedullary plasmacytoma with active multiple myeloma.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plasmocytome
/
Syndrome de compression médullaire
/
Immunoglobuline A
/
Tumeurs du médiastin
/
Myélome multiple
Limites:
Adult
/
Humans
/
Male
Langue:
En
Journal:
BMJ Case Rep
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique