Regulation of metabolism by circadian rhythms: Support from time-restricted eating, intestinal microbiota & omics analysis.
Life Sci
; 351: 122814, 2024 Aug 15.
Article
de En
| MEDLINE
| ID: mdl-38857654
ABSTRACT
Circadian oscillatory system plays a key role in coordinating the metabolism of most organisms. Perturbation of genetic effects and misalignment of circadian rhythms result in circadian dysfunction and signs of metabolic disorders. The eating-fasting cycle can act on the peripheral circadian clocks, bypassing the photoperiod. Therefore, time-restricted eating (TRE) can improve metabolic health by adjusting eating rhythms, a process achieved through reprogramming of circadian genomes and metabolic programs at different tissue levels or remodeling of the intestinal microbiota, with omics technology allowing visualization of the regulatory processes. Here, we review recent advances in circadian regulation of metabolism, focus on the potential application of TRE for rescuing circadian dysfunction and metabolic disorders with the contribution of intestinal microbiota in between, and summarize the significance of omics technology.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Rythme circadien
/
Microbiome gastro-intestinal
Limites:
Animals
/
Humans
Langue:
En
Journal:
Life Sci
Année:
2024
Type de document:
Article