Atypical BCR-ABL1 transcript in mixed phenotype acute leukemia with bone marrow necrosis.
Mol Carcinog
; 63(8): 1429-1435, 2024 Aug.
Article
de En
| MEDLINE
| ID: mdl-38860593
ABSTRACT
Mixed phenotype acute leukemia (MPAL) is a type of acute leukemia in which encompasses mixed features of myeloid, T-lymphoid, and/or B-lymphoid differentiation. Philadelphia chromosome-positive (Ph+) MPAL is a rare subgroup with a poor prognosis and accounts for ï¼1% of adult acute leukemia. Until now, there is still no consensus on how to best treat Ph+ MPAL. Here, we report a 62-year-old male with Ph+ (atypical e13a2 BCR-ABL1 fusion protein) MPAL. This patient presented with recurrent and intense bone pain due to bone marrow necrosis (BMN). Besides, he did not achieve a complete remission for the first two chemotherapies, until he received flumatinib combined with hyper-CVAD (B) (a dose-intensive regimen include methotrexate and cytarabine). To our knowledge, this is the first report to describe the coexistence of BMN and atypical e13a2 BCR-ABL1 transcripts in patients with MPAL. This finding will bring new understandings in the diagnosis and treatment of Ph+ MPAL.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Moelle osseuse
/
Protéines de fusion bcr-abl
/
Nécrose
Limites:
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Mol Carcinog
/
Mol. Carcinog
/
Molecular carcinogenesis
Sujet du journal:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
États-Unis d'Amérique