Crystal-packing analysis of translation initiation factor 2 reveals new details of its function.
Acta Crystallogr D Struct Biol
; 80(Pt 7): 464-473, 2024 Jul 01.
Article
de En
| MEDLINE
| ID: mdl-38860981
ABSTRACT
Eukaryotic and archaeal translation initiation factor 2 in complex with GTP delivers the initiator methionyl-tRNA to the small ribosomal subunit. Over the past 20 years, thanks to the efforts of various research groups, including ours, this factor from the archaeon Sulfolobus solfataricus and its individual subunits have been crystallized in ten different space groups. Analysis of the molecular packing in these crystals makes it possible to better understand the roles of functionally significant switches and other elements of the nucleotide-binding pocket during the function of the factor as well as the influence of external effects on its transition between active and inactive states.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéines d'archée
/
Sulfolobus solfataricus
Langue:
En
Journal:
Acta Crystallogr D Struct Biol
/
Acta crystallographica
Année:
2024
Type de document:
Article
Pays de publication:
États-Unis d'Amérique