Right ventricular function indices and platelet parameters for early prediction value of bronchopulmonary dysplasia: a retrospective study.
BMC Pediatr
; 24(1): 391, 2024 Jun 12.
Article
de En
| MEDLINE
| ID: mdl-38862972
ABSTRACT
BACKGROUND:
To examine the value of early echocardiographic indices for the right ventricular function combined with platelet(PLT) parameters for predicting bronchopulmonary dysplasia (BPD) in preterm infants.METHODS:
This retrospective study included infants with gestational age (GA) below 32 weeks, who were admitted to the neonatal intensive care unit(NICU). The detection rate of tricuspid regurgitation jet velocity (TRVJ), ventricular septal flattening, pulmonary artery widening, right ventricular dilation, and right atrial enlargement on the 7th day of life (DOL 7) were compared between BPD and non-BPD infants. Echocardiographic indices of the right ventricular function including tricuspid annular plane systolic excursion (TAPSE) and right ventricular index of myocardial performance (RIMP) were measured on 1 day of life (DOL 1)ãon DOL 7 and on 14 day of life (DOL 14) respectively. The PLT parameters including the PLT count, mean platelet volume (MPV), platelet hematocrit (PCT) level, and platelet distribution width (PDW) were measured on the DOL 1,DOL 7, and DOL 14. Multivariate logistic regression was used to analyze the relationship between these parameters and BPD. Receiver operating characteristic curve analysis was performed to assess the predictive value of the right ventricular function indices and PLT parameters for BPD.RESULTS:
A total of 220 preterm infants were included in this study, and of these, 85 infants developed BPD among them. The RIMP of the BPD group on DOL 14 was higher than that of the non-BPD group (P < 0.05). The TAPSE of the BPD group on DOL 14 was lower than that of the non-BPD group (P < 0.05). The PLT count of the BPD group on DOL 1 was lower than that of the non-BPD group (P < 0.05), and the MPV of the BPD group on DOL 1 was higher than that of the non-BPD group (P < 0.05). Using multivariate logistic regression, GAãinvasive mechanical ventilation duration ≥ 7 daysã PLTã MPVã TAPSE and RIMP were found to be independent risk factors for BPD. The area under the receiver operating characteristic curve was 0.846 (95CI 0.794â¼0.899), which improved when using right ventricular function indices combined with platelet parameters.CONCLUSION:
TAPSE and RIMP combined with PLT count and MPV can help identify preterm infants at an increased risk of developing BPD.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Dysplasie bronchopulmonaire
/
Prématuré
Limites:
Female
/
Humans
/
Male
/
Newborn
Langue:
En
Journal:
BMC Pediatr
Sujet du journal:
PEDIATRIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine