Cancer-associated fibroblasts: heterogeneity and their role in the tumor immune response.
Clin Exp Med
; 24(1): 126, 2024 Jun 12.
Article
de En
| MEDLINE
| ID: mdl-38864912
ABSTRACT
In recent decades, many reports have been published on the composition and function of the tumor microenvironment (TME), among which cancer-associated fibroblasts (CAFs) have received much attention. CAFs have different degrees of heterogeneity in terms of their origin, phenotype, and function and can be divided into different subpopulations. These subgroups may play different roles in the occurrence and development of tumors. In addition, CAFs are closely associated with tumor immunity and have been found to regulate immune cell activity and to suppress the tumor immune response. In this review, we systematize the heterogeneity and characteristics of CAFs, discuss how specific CAF subgroups contribute to cancer progression by inducing an immunosuppressive microenvironment, and finally, we examine the future clinical applications of CAF subgroups.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Microenvironnement tumoral
/
Fibroblastes associés au cancer
/
Tumeurs
Limites:
Humans
Langue:
En
Journal:
Clin Exp Med
Sujet du journal:
MEDICINA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Italie