Novel strategies for targeting neutrophil against myocardial infarction.
Pharmacol Res
; 205: 107256, 2024 Jul.
Article
de En
| MEDLINE
| ID: mdl-38866263
ABSTRACT
Inflammation is a crucial factor in cardiac remodeling after acute myocardial infarction (MI). Neutrophils, as the first wave of leukocytes to infiltrate the injured myocardium, exacerbate inflammation and cardiac injury. However, therapies that deplete neutrophils to manage cardiac remodeling after MI have not consistently produced promising outcomes. Recent studies have revealed that neutrophils at different time points and locations may have distinct functions. Thus, transferring neutrophil phenotypes, rather than simply blocking their activities, potentially meet the needs of cardiac repair. In this review, we focus on discussing the fate, heterogeneity, functions of neutrophils, and attempt to provide a more comprehensive understanding of their roles and targeting strategies in MI. We highlight the strategies and translational potential of targeting neutrophils to limit cardiac injury to reduce morbidity and mortality from MI.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Infarctus du myocarde
/
Granulocytes neutrophiles
Limites:
Animals
/
Humans
Langue:
En
Journal:
Pharmacol Res
/
Pharmacol. res
/
Pharmacological Research
Sujet du journal:
FARMACOLOGIA
Année:
2024
Type de document:
Article
Pays de publication:
Pays-Bas