Strategy for Clinical Setting of Co-transplantation of Mesenchymal Stem Cells and Pancreatic Islets.
Cell Transplant
; 33: 9636897241259433, 2024.
Article
de En
| MEDLINE
| ID: mdl-38877672
ABSTRACT
Islet transplantation may be the most efficient therapeutic technique for patients with type 1 diabetes mellitus (T1DM). However, the clinical application of this method is faced with numerous limitations, including isolated islet apoptosis, recipient rejection, and graft vascular reconstruction. Mesenchymal stem cells (MSCs) possess anti-apoptotic, immunomodulatory, and angiogenic properties. Here, we review recent studies on co-culture and co-transplantation of islets with MSCs. We have summarized the methods of preparation of co-transplantation, especially the merits of co-culture, and the effects of co-transplantation. Accumulating experimental evidence shows that co-culture of islets with MSCs promotes islet survival, enhances islet secretory function, and prevascularizes islets through various pretransplant preparations. This review is expected to provide a reference for exploring the use of MSCs for clinical islet co-transplantation.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Transplantation d'ilots de Langerhans
/
Ilots pancréatiques
/
Techniques de coculture
/
Transplantation de cellules souches mésenchymateuses
/
Cellules souches mésenchymateuses
Limites:
Animals
/
Humans
Langue:
En
Journal:
Cell Transplant
Sujet du journal:
TRANSPLANTE
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine