The clinical utility of diffusion-weighted imaging in diagnosing and predicting treatment response of laryngeal and hypopharyngeal carcinoma: A systematic review and meta-analysis.
Eur J Radiol
; 177: 111550, 2024 Aug.
Article
de En
| MEDLINE
| ID: mdl-38878501
ABSTRACT
PURPOSE:
Laryngeal and Hypopharyngeal Carcinomas (LC/HPC) constitute about 24â¯% of head and neck cancers, causing more than 90,000 annual deaths worldwide. Diffusion-Weighted Imaging (DWI), is currently widely studied in oncologic imaging and can aid in distinguishing cellular tumors from other tissues. Our objective was to review the effectiveness of DWI in three areas diagnosing, predicting prognosis, and predicting treatment response in patients with LC/HPC.METHODS:
A systematic search was conducted in PubMed, Web of Science, and Embase. A meta-analysis by calculating Standardized Mean Difference (SMD) and 95â¯% Confidence Interval (CI) was conducted on diagnostic studies.RESULTS:
A total of 16 studies were included. All diagnostic studies (nâ¯=â¯9) were able to differentiate between the LC/HPC and other benign laryngeal/hypopharyngeal lesions. These studies found that LC/HPC had lower Apparent Diffusion Coefficient (ADC) values than non-cancerous lesions. Our meta-analysis of 7 diagnostic studies, that provided ADC values of malignant and non-malignant tissues, demonstrated significantly lower ADC values in LC/HPC compared to non-malignant lesions (SMDâ¯=â¯-1.71, 95â¯%CI [-2.00, -1.42], ADC cut-offâ¯=â¯1.2â¯×â¯103â¯mm2/s). Furthermore, among the studies predicting prognosis, 67â¯% (4/6) accurately predicted outcomes based on pretreatment ADC values. Similarly, among studies predicting treatment response, 50â¯% (2/4) successfully predicted outcomes based on pretreatment ADC values. Overall, the studies that looked at prognosis or treatment response in LC/HPC found a positive correlation between pretreatment ADC values in larynx/hypopharynx and favorable outcomes.CONCLUSION:
DWI aids significantly in the LC/HPC diagnosis. However, further research is needed to establish DWI's reliability in predicting prognosis and treatment response in patients with LC/HPC.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de l'hypopharynx
/
Tumeurs du larynx
/
Imagerie par résonance magnétique de diffusion
Limites:
Humans
Langue:
En
Journal:
Eur J Radiol
/
Eur. j. radiol
/
European journal of radiology
Année:
2024
Type de document:
Article
Pays d'affiliation:
Iran
Pays de publication:
Irlande