Molecular Pathways and Animal Models of Truncus Arteriosus.
Adv Exp Med Biol
; 1441: 853-865, 2024.
Article
de En
| MEDLINE
| ID: mdl-38884754
ABSTRACT
In normal cardiovascular development in birds and mammals, the outflow tract of the heart is divided into two distinct channels to separate the oxygenated systemic blood flow from the deoxygenated pulmonary circulation. When the process of outflow tract septation fails, a single common outflow vessel persists resulting in a serious clinical condition known as persistent truncus arteriosus or common arterial trunk. In this chapter, we will review molecular pathways and the cells that are known to play a role in the formation and development of the outflow tract and how genetic manipulation of these pathways in animal models can result in common arterial trunk.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tronc artériel commun
/
Modèles animaux de maladie humaine
Limites:
Animals
/
Humans
Langue:
En
Journal:
Adv Exp Med Biol
Année:
2024
Type de document:
Article
Pays d'affiliation:
Royaume-Uni