An endothelial regulatory module links blood pressure regulation with elite athletic performance.
PLoS Genet
; 20(6): e1011285, 2024 Jun.
Article
de En
| MEDLINE
| ID: mdl-38885195
ABSTRACT
The control of transcription is crucial for homeostasis in mammals. A previous selective sweep analysis of horse racing performance revealed a 19.6 kb candidate regulatory region 50 kb downstream of the Endothelin3 (EDN3) gene. Here, the region was narrowed to a 5.5 kb span of 14 SNVs, with elite and sub-elite haplotypes analyzed for association to racing performance, blood pressure and plasma levels of EDN3 in Coldblooded trotters and Standardbreds. Comparative analysis of human HiCap data identified the span as an enhancer cluster active in endothelial cells, interacting with genes relevant to blood pressure regulation. Coldblooded trotters with the sub-elite haplotype had significantly higher blood pressure compared to horses with the elite performing haplotype during exercise. Alleles within the elite haplotype were part of the standing variation in pre-domestication horses, and have risen in frequency during the era of breed development and selection. These results advance our understanding of the molecular genetics of athletic performance and vascular traits in both horses and humans.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pression sanguine
/
Haplotypes
/
Performance sportive
Limites:
Animals
/
Humans
/
Male
Langue:
En
Journal:
PLoS Genet
/
PloS genet
/
PloS genetics
Sujet du journal:
GENETICA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Suède
Pays de publication:
États-Unis d'Amérique