Effectiveness of repetitive transcranial magnetic stimulation for insomnia disorder on fear memory extinction: study protocol for a randomised controlled trial.
Trials
; 25(1): 396, 2024 Jun 19.
Article
de En
| MEDLINE
| ID: mdl-38898471
ABSTRACT
BACKGROUND:
Fear memory extinction is closely related to insomnia. Repetitive transcranial magnetic stimulation (rTMS) is safe and effective for treating insomnia disorder (ID), and it has been shown to be an efficient method for modulating fear extinction. However, whether rTMS can improve fear extinction memory in ID patients remains to be studied. In this study, we specifically aim to (1) show that 1 Hz rTMS stimulation could improve fear extinction memory in ID patients and (2) examine whether changes in sleep mediate this impact. METHODS ANDDESIGN:
We propose a parallel group randomised controlled trial of 62 ID participants who meet the inclusion criteria. Participants will be assigned to a real rTMS group or a sham rTMS group. The allocation ratio will be 11, with 31 subjects in each group. Interventions will be administered five times per week over a 4-week period. The assessments will take place at baseline (week 0), post-intervention (week 4), and 8-week follow-up (week 8). The primary outcome measure of this study will be the mean change in the Pittsburgh Sleep Quality Index (PSQI) scores from baseline to post-intervention at week 4. The secondary outcome measures include the mean change in skin conductance response (SCR), fear expectation during fear extinction, Insomnia Severity Index (ISI), Zung Self-Rating Anxiety Scale (SAS), and the Zung Self-Rating Depression Scale (SDS).DISCUSSION:
This study will be the first examination of the impact of rTMS on fear memory extinction in ID patients. TRIAL REGISTRATION Chinese Clinical Trials Register ChiCTR2300076097. Registered on 25 September 2021.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Essais contrôlés randomisés comme sujet
/
Stimulation magnétique transcrânienne
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Extinction (psychologie)
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Peur
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Troubles de l'endormissement et du maintien du sommeil
Limites:
Adolescent
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Adult
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Female
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Humans
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Male
/
Middle aged
Langue:
En
Journal:
Trials
/
Trials (Online)
Sujet du journal:
MEDICINA
/
TERAPEUTICA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Royaume-Uni