Polymer-Based Nanoparticles with Probucol and Lithocholic Acid: A Novel Therapeutic Approach for Oxidative Stress-Induced Retinopathies.
Mol Pharm
; 21(7): 3566-3576, 2024 Jul 01.
Article
de En
| MEDLINE
| ID: mdl-38899552
ABSTRACT
Oxidative stress is pivotal in retinal disease progression, causing dysfunction in various retinal components. An effective antioxidant, such as probucol (PB), is vital to counteract oxidative stress and emerges as a potential candidate for treating retinal degeneration. However, the challenges associated with delivering lipophilic drugs such as PB to the posterior segment of the eye, specifically targeting photoreceptor cells, necessitate innovative solutions. This study uses formulation-based spray dry encapsulation technology to develop polymer-based PB-lithocholic acid (LCA) nanoparticles and assesses their efficacy in the 661W photoreceptor-like cell line. Incorporating LCA enhances nanoparticles' biological efficacy without compromising PB stability. In vitro studies demonstrate that PB-LCA nanoparticles prevent reactive oxygen species (ROS)-induced oxidative stress by improving cellular viability through the nuclear erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. These findings propose PB-LCA nanoparticles as a promising therapeutic strategy for oxidative stress-induced retinopathies.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polymères
/
Probucol
/
Espèces réactives de l'oxygène
/
Stress oxydatif
/
Nanoparticules
/
Acide lithocholique
/
Antioxydants
Limites:
Animals
/
Humans
Langue:
En
Journal:
Mol Pharm
Sujet du journal:
BIOLOGIA MOLECULAR
/
FARMACIA
/
FARMACOLOGIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Australie