Structures, biosynthesis and biological activities of benastatins, anthrabenzoxocinones and fredericamycins.
Bioorg Chem
; 150: 107572, 2024 Sep.
Article
de En
| MEDLINE
| ID: mdl-38901281
ABSTRACT
The fast spread of antibiotic resistance results in the requirement for a constant introduction of new candidates. Pentangular polyphenols, a growing family of actinomycetes-derived aromatic type II polyketides, have attracted considerable attention due to their intriguing polycyclic systems and potent antimicrobial activity. Among them, benastatins, anthrabenzoxocinones (ABXs), and fredericamycins, display unique variations in their polycyclic frameworks, yet concurrently share structural commonalities within their substitutions. The present review summarizes advances in the isolation, spectroscopic characteristics, biosynthesis, and biological activities of pentangular polyphenols benastatins (1-16), ABXs (17-39), and fredericamycins (40-42) from actinomycetes. The information presented here thus prompts researchers to further explore and discover additional congeners within these three small classes of pentangular polyphenols.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Antibactériens
Limites:
Humans
Langue:
En
Journal:
Bioorg Chem
Année:
2024
Type de document:
Article
Pays d'affiliation:
Cameroun
Pays de publication:
États-Unis d'Amérique