Targeted discovery of unusual diterpenoids with anti-fungal activity from the root of Euphorbia lathyris.
Phytochemistry
; 225: 114193, 2024 Sep.
Article
de En
| MEDLINE
| ID: mdl-38908463
ABSTRACT
Lathyrisone A (1), a diterpene with an undescribed tricyclic 6/6/6 fused carbon skeleton, along with spirolathyrisins B-D (3-5), three diterpenes with a rare [4.5.0] spirocyclic carbon skeleton, and one known compound (2) were isolated from the roots of Euphorbia lathyris. Their chemical structures were characterized by extensive spectroscopic analysis, X-ray crystallography, ECD and quantum chemistry calculation. A plausible biosynthetic pathway for compounds 1-5 was proposed, which suggested it is a competitive pathway for ingenol biosynthesis in the plant. The anti-fungal activities of these compounds were tested, especially, compound 2 showed stronger anti-fungal activities against Fusarium oxysporum and Alternaria alternata than the positive control fungicide thiophanate-methyl. The preliminary structure-activity relationship of compounds 1-5 was also discussed. These results not only expanded the chemical diversities of E. lathyris, but also provided a lead compound for the control of plant pathogens.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tests de sensibilité microbienne
/
Racines de plante
/
Euphorbia
/
Diterpènes
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Alternaria
/
Fusarium
/
Antifongiques
Langue:
En
Journal:
Phytochemistry
Année:
2024
Type de document:
Article