Acesulfame potassium triggers inflammatory bowel disease via the inhibition of focal adhesion pathway.
J Hazard Mater
; 476: 134901, 2024 Sep 05.
Article
de En
| MEDLINE
| ID: mdl-38909462
ABSTRACT
Acesulfame potassium (ACK) was generally regarded as innocuous and extensively ingested. Nevertheless, ACK has recently gained attention as a burgeoning pollutant that has the potential to induce a range of health hazards, particularly to the digestive system. Herein, we uncover that ACK initiates inflammatory bowel disease (IBD) in mice and zebrafish, as indicated by the aggregation of macrophages in the intestine and the inhibition of intestinal mucus secretion. Transcriptome analysis of mice and zebrafish guts revealed that exposure to ACK typically impacts the cell cycle, focal adhesion, and PI3K-Akt signaling pathways. Using pharmacological approaches, we demonstrate that the PI3K-Akt signaling pathway and the generation of reactive oxygen species (ROS) triggered by cell division are not significant factors in the initiation of IBD caused by ACK. Remarkably, inhibition of the focal adhesion pathway is responsible for the IBD onset induced by ACK. Our results indicate the detrimental impacts and possible underlying mechanisms of ACK on the gastrointestinal system and provide insights for making informed choices about everyday dietary habits.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Thiazines
/
Danio zébré
/
Maladies inflammatoires intestinales
/
Transduction du signal
/
Contacts focaux
Limites:
Animals
Langue:
En
Journal:
J Hazard Mater
Sujet du journal:
SAUDE AMBIENTAL
Année:
2024
Type de document:
Article