Research progress of microRNA in spinal cord injury.
Sheng Li Xue Bao
; 76(3): 394-406, 2024 Jun 25.
Article
de En
| MEDLINE
| ID: mdl-38939934
ABSTRACT
Spinal cord injury (SCI) is a serious central nervous system disease with high disability and mortality rates and complex pathophysiologic mechanisms. MicroRNA (miRNA), as a kind of non-coding RNA, plays an important role in SCI. miRNA is involved in the regulation of inflammatory response, oxidative stress, axonal regeneration, and apoptosis after SCI, and interacts with long non-coding RNA (lncRNA) and circular RNA (circRNA) to regulate the pathophysiological process of SCI. This paper summarizes the changes in miRNA expression after SCI, and reviews the targeting mechanism of miRNA in SCI and the current research status of miRNA-targeted drugs to provide new targets and new horizons for basic and clinical research on SCI.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Traumatismes de la moelle épinière
/
MicroARN
Limites:
Animals
/
Humans
Langue:
En
Journal:
Sheng Li Xue Bao
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine