Immunoglobulin G4-related thoracic disease: clinical and radiological findings of a Turkish cohort.
Sarcoidosis Vasc Diffuse Lung Dis
; 41(2): e2024030, 2024 Jun 28.
Article
de En
| MEDLINE
| ID: mdl-38940718
ABSTRACT
BACKGROUND AND AIM:
Thoracic involvement of Immunoglobulin G4-related disease (IgG4-RD) is relatively rare and may be disregarded at the time of initial diagnosis due to its asymptomatic nature. This study aimed to ascertain the prevalence and patterns of thoracic involvement in a retrospective cohort of Turkish patients with IgG4-RD.METHODS:
A total of 90 patients (47 males and 43 females, with a mean age of 57.7±15.5 years) diagnosed with IgG4-RD were reviewed retrospectively. All computed tomography (CT) scans were re-evaluated by two thoracic radiologists and IgG4-related thoracic disease was assessed on four compartments The mediastinum, pulmonary parenchyma, airways, and pleura. IgG4-related thoracic disease was categorized as definite, highly probable, probable or possible.RESULTS:
There were 64 patients who had undergone at least one thorax CT examination, and 18 (28%) were diagnosed with IgG4-related thoracic disease. The rate of IgG4-related thoracic disease increased by 20% and reached a ratio of 48.4% (n=31) after a thorough reevaluation of registry data specifically to thoracic findings. The mediastinum was the most frequently involved compartment, affecting 16 (51.6%) patients, followed by pulmonary parenchyma in 14 (45.2%) patients, and airways and pleura in 10 (32.3%) patients each. Other organ involvements were more prevalent and IgG4 levels were higher in patients with thoracic involvement. Eosinophils were significantly elevated in patients with thoracic involvement (p=0.023).CONCLUSIONS:
IgG4-related thoracic disease is heterogeneous and likely to be more prevalent than currently recognized. The mediastinum is the most frequently involved compartment. It is important to assess IgG4-related thoracic disease at the time of initial diagnosis. Elevated levels of serum IgG4 and eosinophils, as well as a greater number of organ involvements may serve as indicators of thoracic involvement.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
Sarcoidosis Vasc Diffuse Lung Dis
/
Sarcoidosis vasc. diffuse lung dis
/
Sarcoidosis, vasculitis, and diffuse lung diseases
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
ANGIOLOGIA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Turquie
Pays de publication:
Italie