Biosynthesis of Natural and Unnatural Perylenequinones for Drug Development.
ChemMedChem
; : e202400295, 2024 Jun 28.
Article
de En
| MEDLINE
| ID: mdl-38943237
ABSTRACT
A wide range of perylenequinones (PQs) with diverse structures and versatile bioactivities have long been isolated, positioning them as highly promising agents for photodynamic therapy (PDT). However, the lack of an efficient and cost-effective method to obtain these compounds and to introduce structural diversity and complexity currently hinders their further research and application. In this concept, we present a comprehensive overview of the advancements in the biosynthetic pathways of natural PQs based on their structural classification, and also summarize recent progress in the biosynthesis of natural PQs and derivatives. These pioneering efforts may pave the way for structure modification and large-scale bioproduction of natural and unnatural PQs through synthetic biology strategies to promote their drug development.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
ChemMedChem
Sujet du journal:
FARMACOLOGIA
/
QUIMICA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine