Ischemic stroke and the emerging role of left atrial function.
Expert Rev Cardiovasc Ther
; 22(7): 289-300, 2024 Jul.
Article
de En
| MEDLINE
| ID: mdl-38943632
ABSTRACT
INTRODUCTION:
Ischemic stroke is a leading cause of morbidity and mortality worldwide. Emerging evidence suggests that left atrial (LA) dysfunction could play a role in the pathophysiology of ischemic stroke, as a possible contributor and as a predictive biomarker. AREAS COVERED This narrative review details the intricate relationship between LA function, atrial fibrillation (AF), and ischemic stroke. We discuss imaging techniques used to assess LA function, the mechanisms by which impaired LA function may contribute to stroke, and its potential as a prognostic marker of stroke. EXPERT OPINION There is a lack of evidence-based treatments of LA dysfunction in both primary and secondary stroke prevention. This is partly due to the lack of a practical clinical definition and unanswered questions concerning the clinical implications of LA dysfunction in patients without AF. Until such questions are resolved, addressing well-known cardiovascular risk factors, like hypertension and obesity, should be prioritized for preventing AF and ischemic stroke. These risk factors are closely tied to atrial remodeling, emphasizing the importance of targeting primary modifiable factors for preventing future morbidity and mortality.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Fibrillation auriculaire
/
Fonction auriculaire gauche
/
Remodelage auriculaire
/
Accident vasculaire cérébral ischémique
Limites:
Animals
/
Humans
Langue:
En
Journal:
Expert Rev Cardiovasc Ther
/
Expert rev. cardiovasc. ther
/
Expert review of cardiovascular therapy
Sujet du journal:
ANGIOLOGIA
/
CARDIOLOGIA
/
TERAPEUTICA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Danemark
Pays de publication:
Royaume-Uni