Flavonoidal alkaloids: Emerging targets for drug discovery from Nature's bounty.
Fitoterapia
; 177: 106099, 2024 Sep.
Article
de En
| MEDLINE
| ID: mdl-38945491
ABSTRACT
This paper explores the potential of flavonoid alkaloids, a unique class of compounds that contain both flavonoid and alkaloid structures, as emerging targets for drug discovery. These compounds exhibit diverse biological activities, such as anti-inflammatory, anti-cancer, and anti-diabetic effects, which are attributed to the combination of different flavonoid scaffolds and alkaloid groups. Flavonoid alkaloids have attracted researchers' attention due to their diverse structures and important bio-activities. Therefore, this review summarizes recent advances in the extraction, purification, structural characterization, synthesis pathways and biological activities of flavonoid alkaloids from natural sources. Finally, the potential prospects and challenges associated with this class of compounds in pharmacological research are discussed along with details of a mechanistic investigation and future clinical applications in this research field.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Flavonoïdes
/
Alcaloïdes
/
Découverte de médicament
Limites:
Animals
/
Humans
Langue:
En
Journal:
Fitoterapia
Année:
2024
Type de document:
Article
Pays de publication:
Pays-Bas