Drug screening and development cascade for Chagas disease: an update of in vitro and in vivo experimental models.
Mem Inst Oswaldo Cruz
; 119: e240057, 2024.
Article
de En
| MEDLINE
| ID: mdl-38958341
ABSTRACT
Chagas disease is a tropical neglected disease that affects millions of people worldwide, still demanding a more effective and safer therapy, especially in its chronic phase which lacks a treatment that promotes substantial parasitological cure. The technical note of Romanha and collaborators published in 2010 aimed establish a guideline with the set of minimum criteria and decision gates for the development of new agents against Trypanosoma cruzi with the focus on developing new antichagasic drugs. In this sense, the present review aims to update this technical note, bringing the state of the art and new advances on this topic in recent years.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Trypanocides
/
Trypanosoma cruzi
/
Maladie de Chagas
/
Modèles animaux de maladie humaine
/
Évaluation préclinique de médicament
Limites:
Animals
/
Humans
Langue:
En
Journal:
Mem Inst Oswaldo Cruz
Année:
2024
Type de document:
Article
Pays d'affiliation:
Brésil
Pays de publication:
Brésil