A model of microtubule depolymerization by kinesin-8 motor proteins.
Adv Protein Chem Struct Biol
; 141: 87-122, 2024.
Article
de En
| MEDLINE
| ID: mdl-38960488
ABSTRACT
The dimeric kinesin-8 motors have the biological function of depolymerizing microtubules (MTs) from the plus end. However, the molecular mechanism of the depolymerization promoted by the kinesin-8 motors is still undetermined. Here, a model is proposed for the MT depolymerization by the kinesin-8 motors. Based on the model, the dynamics of depolymerization in the presence of the single motor at the MT plus end under no load and under load on the motor is studied theoretically. The dynamics of depolymerization in the presence of multiple motors at the MT plus end is also analyzed. The theoretical results explain well the available experimental data. The studies can also be applicable to other families of kinesin motors such as kinesin-13 mitotic centromere-associated kinesin motors that have the ability to depolymerize MTs.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Kinésine
/
Polymérisation
/
Microtubules
Limites:
Animals
/
Humans
Langue:
En
Journal:
Adv Protein Chem Struct Biol
/
Advances in protein chemistry and structural biology (Online)
Sujet du journal:
BIOLOGIA
/
BIOQUIMICA
Année:
2024
Type de document:
Article
Pays de publication:
Pays-Bas