scDrug+: predicting drug-responses using single-cell transcriptomics and molecular structure.
Biomed Pharmacother
; 177: 117070, 2024 Aug.
Article
de En
| MEDLINE
| ID: mdl-38964180
ABSTRACT
Predicting drug responses based on individual transcriptomic profiles holds promise for refining prognosis and advancing precision medicine. Although many studies have endeavored to predict the responses of known drugs to novel transcriptomic profiles, research into predicting responses for newly discovered drugs remains sparse. In this study, we introduce scDrug+, a comprehensive pipeline that seamlessly integrates single-cell analysis with drug-response prediction. Importantly, scDrug+ is equipped to predict the response of new drugs by analyzing their molecular structures. The open-source tool is available as a Docker container, ensuring ease of deployment and reproducibility. It can be accessed at https//github.com/ailabstw/scDrugplus.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Analyse de profil d'expression de gènes
/
Analyse sur cellule unique
/
Transcriptome
Limites:
Humans
Langue:
En
Journal:
Biomed Pharmacother
Année:
2024
Type de document:
Article
Pays d'affiliation:
Taïwan