Cut from the same cloth: RNAs transcribed from regulatory elements.
Biochim Biophys Acta Gene Regul Mech
; 1867(3): 195049, 2024 Sep.
Article
de En
| MEDLINE
| ID: mdl-38964653
ABSTRACT
A certain degree of chromatin openness is necessary for the activity of transcription-regulating regions within the genome, facilitating accessibility to RNA polymerases and subsequent synthesis of regulatory element RNAs (regRNAs) from these regions. The rapidly increasing number of studies underscores the significance of regRNAs across diverse cellular processes and diseases, challenging the paradigm that these transcripts are non-functional transcriptional noise. This review explores the multifaceted roles of regRNAs in human cells, encompassing rather well-studied entities such as promoter RNAs and enhancer RNAs (eRNAs), while also providing insights into overshadowed silencer RNAs and insulator RNAs. Furthermore, we assess notable examples of shorter regRNAs, like miRNAs, snRNAs, and snoRNAs, playing important roles. Expanding our discourse, we deliberate on the potential usage of regRNAs as biomarkers and novel targets for cancer and other human diseases.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Transcription génétique
Limites:
Animals
/
Humans
Langue:
En
Journal:
Biochim Biophys Acta Gene Regul Mech
Année:
2024
Type de document:
Article
Pays d'affiliation:
Russie
Pays de publication:
Pays-Bas