Cocoa and Polyphenol-Rich Cocoa Fractions Fail to Improve Acute Colonic Inflammation in Dextran Sulfate Sodium-Treated Mice.
Mol Nutr Food Res
; 68(15): e2400431, 2024 Aug.
Article
de En
| MEDLINE
| ID: mdl-38965660
ABSTRACT
SCOPE A study is conducted to determine the anti-inflammatory effects of cocoa and polyphenol-rich cocoa fractions in the dextran sulfate sodium (DSS)-induced mouse model of acute colonic inflammation. METHODS AND RESULTS:
Male C57BL/6J mice are treated with dietary cocoa powder, an extractable cocoa polyphenol fraction, or a non-extractable cocoa polyphenol fraction for 2 weeks prior to treatment with 2.5% DSS in the drinking water for 7 days to induce colonic inflammation. Cocoa treatment continues during the DSS period. Cocoa and/or cocoa fractions exacerbate DSS-induced weight loss and fail to mitigate DSS-induced colon shortening but do improve splenomegaly. Cocoa/cocoa fraction treatment fails to mitigate DSS-induced mRNA and protein markers of inflammation. Principal component analysis shows overlap between cocoa or cocoa fraction-treated mice and DSS-induced controls, but separation from mice not treated with DSS.CONCLUSION:
The results suggest cocoa and cocoa polyphenols may not be useful in mitigating acute colonic inflammation.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cacaoyer
/
Sulfate dextran
/
Colite
/
Côlon
/
Polyphénols
/
Souris de lignée C57BL
Limites:
Animals
Langue:
En
Journal:
Mol Nutr Food Res
/
Mol. nutr. food res. (Print)
/
Molecular nutrition & food research (Print)
Sujet du journal:
CIENCIAS DA NUTRICAO
Année:
2024
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique
Pays de publication:
Allemagne