Artesunate inhibits vasculogenic mimicry in choroidal melanoma through HIF-1 α/ VEGF/PDGF pathway.
Acta Histochem
; 126(5-7): 152174, 2024 Oct.
Article
de En
| MEDLINE
| ID: mdl-38976933
ABSTRACT
Choroidal melanoma (CM), a highly metastatic eye tumor, exhibits vasculogenic mimicry (VM) facilitated by hypoxia-induced angiogenesis. This study explored the inhibitory impact of the anti-malarial drug Artesunate (ART) on CM VM through modulation of the HIF-1α/VEGF/PDGF pathway. Immunohistochemistry (IHC) confirmed VM in CM with elevated VEGF and PDGF expression. Hypoxia promoted CM proliferation, upregulating HIF-1α, VEGF and PDGF. VEGF and PDGF enhanced CM migration, invasion and VM, with HIF-1α playing a crucial role. ART mitigated VM formation by suppressing the HIF-1α/VEGF/PDGF pathway, highlighting its potential as an anti-tumor agent in CM.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Facteur de croissance dérivé des plaquettes
/
Tumeurs de la choroïde
/
Facteur de croissance endothéliale vasculaire de type A
/
Sous-unité alpha du facteur-1 induit par l'hypoxie
/
Artésunate
/
Mélanome
/
Néovascularisation pathologique
Limites:
Humans
/
Male
Langue:
En
Journal:
Acta Histochem
Année:
2024
Type de document:
Article
Pays de publication:
Allemagne