QuantiFERON monitor predicts early cytomegalovirus infection and viral burden in allogeneic hematopoietic stem cell transplantation.
Transpl Infect Dis
; 26(4): e14328, 2024 Aug.
Article
de En
| MEDLINE
| ID: mdl-38980949
ABSTRACT
INTRODUCTION:
Cytomegalovirus (CMV) infection is a major cause of transplantation-related morbidity and mortality. This study assessed the utility of the QuantiFERON monitor (QFM; Qiagen) for the prediction of early CMV infection and viral burden.METHODS:
QuantiFERON-CMV (QF-CMV; Qiagen) and QFM were measured at the post-allogeneic hematopoietic stem cell transplantation (HSCT) week 4. CMV DNA was measured at every visit until post-HSCT week 24. The QFM cutoff specific to CMV infection was established.RESULT:
At the post-HSCT week 4, the QFM cutoff predicting CMV infection was 86.95 IU/mL. While QF-CMV results at the post-HSCT week 4 were associated with high-level CMV infection (CMV DNA ≥ 5,000 IU/mL) but not with CMV infection (CMV DNA ≥ 500 IU/mL), QFM was associated with both CMV infection and high-level CMV infection. Both indeterminate QF-CMV and nonreactive QFM were associated with increased peak CMV DNA.CONCLUSION:
Low QFM is a risk factor for CMV infection and increased CMV viral loads. QFM at post-HSCT week 4 can be utilized as an assay to predict the risk and burden of early CMV infection in HSCT recipients, in conjunction with other risk factors.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Transplantation homologue
/
ADN viral
/
Infections à cytomégalovirus
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Transplantation de cellules souches hématopoïétiques
/
Charge virale
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Cytomegalovirus
Limites:
Adolescent
/
Adult
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Aged
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Female
/
Humans
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Male
/
Middle aged
Langue:
En
Journal:
Transpl Infect Dis
Sujet du journal:
TRANSPLANTE
Année:
2024
Type de document:
Article
Pays d'affiliation:
Corée du Sud