Design, synthesis and biological evaluation of sulfamethazine derivatives as potent neuraminidase inhibitors.
Future Med Chem
; 16(12): 1205-1218, 2024.
Article
de En
| MEDLINE
| ID: mdl-38989986
ABSTRACT
Aim:
The purpose of this study is to design and synthesize a new series of sulfamethazine derivatives as potent neuraminidase inhibitors. Materials &methods:
A sulfamethazine lead compound, ZINC670537, was first identified by structure-based virtual screening technique, then some novel inhibitors X1-X10 based on ZINC670537 were designed and synthesized.Results:
Compound X3 exerts the most good potency in inhibiting the wild-type H5N1 NA (IC50 = 6.74 µM) and the H274Y mutant NA (IC50 = 21.09 µM). 150-cavity occupation is very important in determining activities of these inhibitors. The sulfamethazine moiety also plays an important role.Conclusion:
Compound X3 maybe regard as a good anti-influenza candidate to preform further study.
[Box see text].
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Antiviraux
/
Sulfadimidine
/
Conception de médicament
/
Antienzymes
/
Sous-type H5N1 du virus de la grippe A
/
Sialidase
Limites:
Humans
Langue:
En
Journal:
Future Med Chem
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Royaume-Uni