The Flavonoid Glycoside from Abrus cantoniensis Hance Alleviates Alcoholic Liver Injury by Inhibiting Ferroptosis in an AMPK-Dependent Manner.
J Agric Food Chem
; 72(29): 16323-16333, 2024 Jul 24.
Article
de En
| MEDLINE
| ID: mdl-38990278
ABSTRACT
Abrus cantoniensis Hance is a vegetative food and can be used as a folk beverage or soup to clear liver toxins and prevent liver damage. However, the components and effects of A. cantoniensis Hance in alcohol-induced liver injury were unknown. This study aimed to obtain abundant phytochemicals from A. cantoniensis Hance and identify the potency of the isolates in preventing alcohol-induced liver injury. Alcohol-stimulated AML12 cells and Lieber-DeCarli diet-fed mice were used to establish in vitro and in vivo models, respectively. Our findings indicated that flavonoid glycosides, especially AH-15, could significantly alleviate alcohol-induced liver injury by inhibiting oxidative stress. Furthermore, we demonstrated that AH-15 inhibited ferroptosis induced by lipid peroxidation. Mechanically, we found that AH-15 regulated nuclear factor erythroid 2-related factor 2 (NRF2) expression via activation of AMP-activated protein kinase (AMPK) signaling. These results indicate that A. cantoniensis Hance is a great potential functional food for alleviating alcohol-induced liver injury.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Flavonoïdes
/
Extraits de plantes
/
Abrus
/
Facteur-2 apparenté à NF-E2
/
AMP-Activated Protein Kinases
/
Ferroptose
/
Hétérosides
/
Maladies alcooliques du foie
/
Souris de lignée C57BL
Limites:
Animals
/
Humans
/
Male
Langue:
En
Journal:
J Agric Food Chem
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine