The relationship between nucleosome positioning and higher-order genome folding.
Curr Opin Cell Biol
; 89: 102398, 2024 Aug.
Article
de En
| MEDLINE
| ID: mdl-38991477
ABSTRACT
Eukaryotic genomes are organized into 3D structures, which range from small-scale nucleosome arrays to large-scale chromatin domains. These structures have an important role in the regulation of transcription and other nuclear processes. Despite advances in our understanding of the properties, functions, and underlying mechanisms of genome structures, there are many open questions about the interplay between these structures across scales. In particular, it is not well understood if and how 1D features of nucleosome arrays influence large-scale 3D genome folding patterns. In this review, we discuss recent studies that address these questions and summarize our current understanding of the relationship between nucleosome positioning and higher-order genome folding.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Nucléosomes
/
Génome
Limites:
Animals
/
Humans
Langue:
En
Journal:
Curr Opin Cell Biol
/
Curr. opin. cell biol
/
Current opinion in cell biology
Année:
2024
Type de document:
Article
Pays d'affiliation:
Allemagne
Pays de publication:
Royaume-Uni