Reevaluation by the CRISPR/Cas9 knockout approach revealed that multiple pluripotency-associated lncRNAs are dispensable for pluripotency maintenance while Snora73a/b is essential for pluripotency exit.

Li, Zhen; Li, Xuefei; Lin, Jingxia; Wang, Yangming; Cao, Huiqing; Zhou, Jiajian

Li, Zhen; Li, Xuefei; Lin, Jingxia; Wang, Yangming; Cao, Huiqing; Zhou, Jiajian.

Affiliation

Li Z; Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, 100871, China.
Li X; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
Lin J; Dermatology Hospital, Southern Medical University, Guangzhou, 510091, China.
Wang Y; Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, 100871, China.
Cao H; Beijing Advanced Center of RNA Biology (BEACON), Peking University, Beijing, 100871, China.
Zhou J; Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, 100871, China. caohuiqing@pku.edu.cn.

Sci China Life Sci ; 2024 Jul 09.

Article de En | MEDLINE | ID: mdl-38995489

Mots clés

CRISPR/Cas9; embryonic stem cells; long noncoding RNAs; snoRNAs; stem cell differentiation

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: Sci China Life Sci Sujet du journal: BIOLOGIA / CIENCIA Année: 2024 Type de document: Article Pays d'affiliation: Chine Pays de publication: Chine

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