The impact of endocrine-disrupting chemicals on stem cells: Mechanisms and implications for human health.
J Environ Sci (China)
; 147: 294-309, 2025 Jan.
Article
de En
| MEDLINE
| ID: mdl-39003048
ABSTRACT
Endocrine-disrupting chemicals (EDCs) are compounds, either natural or man-made, that interfere with the normal functioning of the endocrine system. There is increasing evidence that exposure to EDCs can have profound adverse effects on reproduction, metabolic disorders, neurological alterations, and increased risk of hormone-dependent cancer. Stem cells (SCs) are integral to these pathological processes, and it is therefore crucial to understand how EDCs may influence SC functionality. This review examines the literature on different types of EDCs and their effects on various types of SCs, including embryonic, adult, and cancer SCs. Possible molecular mechanisms through which EDCs may influence the phenotype of SCs are also evaluated. Finally, the possible implications of these effects on human health are discussed. The available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways, including by altering hormonal pathways, DNA damage, epigenetic changes, reactive oxygen species production and alterations in the gene expression patterns. These disruptions may lead to a variety of cell fates and diseases later in adulthood including increased risk of endocrine disorders, obesity, infertility, reproductive abnormalities, and cancer. Therefore, the review emphasizes the importance of raising broader awareness regarding the intricate impact of EDCs on human health.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cellules souches
/
Perturbateurs endocriniens
Limites:
Humans
Langue:
En
Journal:
J Environ Sci (China)
/
Journal of Environmental Sciences (China)
/
Journal of environmental sciences (Online)
Sujet du journal:
SAUDE AMBIENTAL
Année:
2025
Type de document:
Article
Pays de publication:
Pays-Bas