Research progress on the effect of sperm chromatin integrity on function and its detection methods.
Yi Chuan
; 46(7): 511-529, 2024 Jul.
Article
de En
| MEDLINE
| ID: mdl-39016085
ABSTRACT
Sperm chromatin not only carries genetic information such as paternal DNA, but also carries structural proteins, epigenetic information, and higher-order chromatin structures (such as matrix attachment regions and telomeres), etc. These information play an important role in embryonic development. This article mainly reviews the effects of these different information carried by sperm chromatin on sperm function and embryonic development and the research progress of related detection methods, in order to provide a theoretical basis and scientific diagnosis and treatment strategies for the etiology screening of clinical infertility, embryo arrest and recurrent miscarriage, so as to improve the pregnancy outcomes of natural conception and assisted reproduction. Keywords sperm chromatin; epigenetics; sperm DNA damage; sperm function; higher-order chromatin structures.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Spermatozoïdes
/
Chromatine
Limites:
Animals
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Yi Chuan
Sujet du journal:
GENETICA
Année:
2024
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Chine