Numb-associated kinases regulate sandfly-borne Toscana virus entry.
Emerg Microbes Infect
; 13(1): 2382237, 2024 Dec.
Article
de En
| MEDLINE
| ID: mdl-39017647
ABSTRACT
Sandfly-borne Toscana virus (TOSV) is an enveloped tri-segmented negative single-strand RNA Phlebovirus. It is an emerging virus predominantly endemic in southwestern Europe and Northern Africa. Although TOSV infection is typically asymptomatic or results in mild febrile disease, it is neurovirulent and ranks among the three most common causes of summer meningitis in certain regions. Despite this clinical significance, our understanding of the molecular aspects and host factors regulating phlebovirus infection is limited. This study characterized the early steps of TOSV infection. Our findings reveal that two members of the Numb-associated kinases family of Ser/Thr kinases, namely adaptor-associated kinase 1 (AAK1) and cyclin G-associated kinase (GAK), play a role in regulating the early stages of TOSV entry. FDA-approved inhibitors targeting these kinases demonstrated significant inhibition of TOSV infection. This study suggests that AAK1 and GAK represent druggable targets for inhibiting TOSV infection and, potentially, related Phleboviruses.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Virus de la fièvre à phlébotomes de Naples
/
Pénétration virale
Limites:
Animals
/
Humans
Langue:
En
Journal:
Emerg Microbes Infect
Année:
2024
Type de document:
Article
Pays d'affiliation:
Israël
Pays de publication:
États-Unis d'Amérique