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Association of remnant cholesterol with renal function and its progression in patients with type 2 diabetes related chronic kidney disease.
Li, Qiuhong; Wang, Tongdan; Shao, Xian; Fan, Xiaoguang; Lin, Yao; Cui, Zhuang; Liu, Hongyan; Zhou, Saijun; Yu, Pei.
Affiliation
  • Li Q; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
  • Wang T; Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, China.
  • Shao X; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
  • Fan X; Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, China.
  • Lin Y; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
  • Cui Z; Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, China.
  • Liu H; Department of Nephrology, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, China.
  • Zhou S; NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
  • Yu P; Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University, Tianjin, China.
Front Endocrinol (Lausanne) ; 15: 1331603, 2024.
Article de En | MEDLINE | ID: mdl-39027471
ABSTRACT

Background:

The association of Remnant cholesterol (RC) with renal function and its progression in patients with Type 2 diabetes (T2DM) related chronic kidney disease (CKD) remains unclear.

Methods:

8,678 patients with T2DM-related CKD were included in cross-sectional analysis, and 6,165 patients were enrolled in longitudinal analysis and followed up for a median of 36.0 months. The outcomes were renal composite endpoint event and rapid progression of renal function.

Results:

24.54% developed a renal composite endpoint event, and 27.64% rapid progression of renal function. RC levels above 0.56 mmol/L independently increased the risk of both renal composite endpoint (HR, 1.17; 95% CIs, 1.03-1.33) and rapid progression of renal function (OR, 1.17; 95% CIs, 1.01- 1.37). TG levels above 1.65 mmol/L only increased the risk of renal composite endpoint (HR, 1.16; 95% CIs, 1.02 -1.32). TC levels above 5.21 mmol/L increased the risk of renal composite endpoint (HR, 1.14; 95% CIs, 1.01-1.29) only in patients with proteinuria≥0.5g/d. Conversely, HDL-C levels below 1.20 mmol/L or above 1.84 mmol/L increased the risk of rapid progression of renal function (OR, 0.88; 95% CIs, 0.70 -0.99) in patients with proteinuria<0.5g/d (all P<0.05).

Conclusion:

In patients with T2DM-related CKD, RC was an independent risk factor for progression of renal function, and maintaining it below 0.56 mmol/L could reduce the risk of renal function progression.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cholestérol / Évolution de la maladie / Diabète de type 2 / Néphropathies diabétiques / Insuffisance rénale chronique Limites: Aged / Female / Humans / Male / Middle aged Langue: En Journal: Front Endocrinol (Lausanne) Année: 2024 Type de document: Article Pays d'affiliation: Chine

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cholestérol / Évolution de la maladie / Diabète de type 2 / Néphropathies diabétiques / Insuffisance rénale chronique Limites: Aged / Female / Humans / Male / Middle aged Langue: En Journal: Front Endocrinol (Lausanne) Année: 2024 Type de document: Article Pays d'affiliation: Chine