Generation of induced pluripotent stem cell line (XWHNi003-A) from a female with APOE gene mutation.

Gong, Jin; Li, Shaoqi; Sun, Wenxian; Wang, Pin; Han, Xiaodong; Xu, Chang; Chen, Yufei; Yang, Yuting; Luan, Heya; Li, Ruina; Wen, Boye; Lv, Sirong; Chen, Runqi; Guo, Jinxuan; Wei, Cuibai

Gong, Jin; Li, Shaoqi; Sun, Wenxian; Wang, Pin; Han, Xiaodong; Xu, Chang; Chen, Yufei; Yang, Yuting; Luan, Heya; Li, Ruina; Wen, Boye; Lv, Sirong; Chen, Runqi; Guo, Jinxuan; Wei, Cuibai.

Affiliation

Gong J; College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases,
Li S; College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases,
Sun W; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Wang P; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Han X; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Xu C; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Chen Y; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Yang Y; School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Luan H; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Li R; School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Wen B; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Lv S; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China.
Chen R; School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Guo J; College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China.
Wei C; Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China. Electronic address: weicb@xwhosp.org.

Stem Cell Res ; 79: 103501, 2024 Sep.

Article de En | MEDLINE | ID: mdl-39029293

ABSTRACT

ABSTRACT

Apolipoprotein E (APOE)is the gene with greatest genetic risk for Alzheimer's disease (AD). We successfully established a human induced pluripotent stem cell(iPSC) line from a woman mutated by APOE gene. The cell line was isolated from this woman's peripheral blood mononuclear cells using a non-integrated Sendai virus, which retained the original genotype, showed a normal karyotype, highly expressed pluripotent markers and could differentiate into three germ layers.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Apolipoprotéines E / Cellules souches pluripotentes induites / Mutation Limites: Female / Humans Langue: En Journal: Stem Cell Res Année: 2024 Type de document: Article

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