Generation of induced pluripotent stem cell line (XWHNi003-A) from a female with APOE gene mutation.
Stem Cell Res
; 79: 103501, 2024 Sep.
Article
de En
| MEDLINE
| ID: mdl-39029293
ABSTRACT
Apolipoprotein E (APOE)is the gene with greatest genetic risk for Alzheimer's disease (AD). We successfully established a human induced pluripotent stem cell(iPSC) line from a woman mutated by APOE gene. The cell line was isolated from this woman's peripheral blood mononuclear cells using a non-integrated Sendai virus, which retained the original genotype, showed a normal karyotype, highly expressed pluripotent markers and could differentiate into three germ layers.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Apolipoprotéines E
/
Cellules souches pluripotentes induites
/
Mutation
Limites:
Female
/
Humans
Langue:
En
Journal:
Stem Cell Res
Année:
2024
Type de document:
Article