Protective role of macrophages from maternal-fetal interface in unvaccinated coronavirus disease 2019 pregnant women.
J Med Virol
; 96(7): e29819, 2024 Jul.
Article
de En
| MEDLINE
| ID: mdl-39030992
ABSTRACT
Pregnant women represent a high-risk population for Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection. The presence of SARS-CoV-2 has been reported in placenta from infected pregnant women, but whether the virus influences placenta immune response remains unclear. We investigated the properties of maternal-fetal interface macrophages (MFMs) in a cohort of unvaccinated women who contracted coronavirus disease 2019 (COVID-19) during their pregnancy. We reported an infiltration of CD163+ macrophages in placenta from COVID-19 women 19 whereas lymphoid compartment was not affected. Isolated MFMs exhibited nonpolarized activated signature (NOS2, IDO1, IFNG, TNF, TGFB) mainly in women infected during the second trimester of pregnancy. COVID-19 during pregnancy primed MFM to produce type I and III interferon response to SARS-CoV-2 (Wuhan and δ strains), that were unable to elicit this in MFMs from healthy pregnant women. COVID-19 also primed SARS-CoV-2 internalization by MFM in an angiotensin-converting enzyme 2-dependent manner. Activation and recall responses of MFMs were influenced by fetal sex. Collectively, these findings support a role for MFMs in the local immune response to SARS-CoV-2 infection, provide a basis for protective placental immunity in COVID-19, and highlight the interest of vaccination in pregnant women.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Placenta
/
Complications infectieuses de la grossesse
/
SARS-CoV-2
/
COVID-19
/
Macrophages
Limites:
Adult
/
Female
/
Humans
/
Pregnancy
Langue:
En
Journal:
J Med Virol
Année:
2024
Type de document:
Article
Pays d'affiliation:
France
Pays de publication:
États-Unis d'Amérique